PCB's

To determine how residential exposure to PCB's affected neurobehavioral functions. Skin rashes, tumors, irritability and difficulty with recall and concentration had been associated with residence near a pumping station on a natural gas pipeline. The pump lubricant was 50% PCBs.

The neurobehavioral performance of 98 exposed adults was compared with 58 unexposed referents. Visual fields, balance, blink and reaction time were measured and a neurobehavioral test battery completed with a profile of mood states (POMS) and extensive questionnaires for symptoms, chemical exposures and medical history.

Comparisons of exposed adults to unexposed subjects were adjusted individually for their being five years older with two years less schooling. Exposed subjects had significantly slower simple and choice reaction times and significantly faster sway speeds with eyes closed and open. Their scores on all visual tests were significantly lower with frequent visual field constriction. Scores on Culture Fair, digit symbol, vocabulary and verbal recall were significantly lower. Placement of pegs in a slotted pegboard was slower and trail making A and B took longer. Even embedded memory scores (information, picture completion and similarities) were lower. POMS scores were significantly elevated. No competing chemical exposure, confounding factors or other attributable causes were found and tester bias was minimal.

Residential exposure to PCBs since the mid 1950's was associated with severe visual defects and impaired neurophysiologic and neuropsychologic functions.