KAYE H. KILBURN, M.D.
CURRICULUM VITAE
Present Positions:
Ralph Edgington Professor of Medicine, University of Southern California Keck School of Medicine, Director of Environmental Sciences Lab, 1980-2006
President & Director, Neuro-Test, Inc. 1987-present
Editor-in-Chief, Archives of Environmental Health, 1986-2006
Office Address:
Neuro-Test Inc.
P.O. Box 5374
Telephone: 626-798-4299
FAX: 626-798-3859
Email: KKneurotoxdoc@aol.com
Education:
University of Utah, B.S. (Honors), 1951.
University of Utah, School of Medicine, M.D., 1954.
Postgraduate Training:
Rotating Intern, St. Mark's Hospital, Salt Lake City, Utah April - June, 1954.
Intern-Medicine, University Hospitals, Cleveland, Ohio, 1954-1955.
Assistant Resident-Medicine University of Utah Hospitals Salt Lake City, Utah, 1955-1956.
Resident-Pathology and Medicine, Veterans Administration Hospital, Salt Lake City, Utah, 1956-1957
Research Fellow in Medicine, Duke University Hospital, Durham, North Carolina, 1957-1958.
American Trudeau Society Research, Fellow, 1958.
U.S.P.H.S. Research Fellow with Dr. Paul Wood, Cardiac Department, Brompton Hospital, London, England, 1960-1961.
Sabbatical, 1968-Cell biology and ultrastructure, J. David Robertson, M.D., Professor of Anatomy, Duke University, U.S.P.H.S.
Special Fellowship.
Research Career Development Award, NIEHS, 1969-1973.
Certified American Board of Internal Medicine, 1963.
American Board of Preventive Medicine (Occupational Health) 1983.
Military Service:
Chief, Surgery Branch, Physiology Division, U.S. Army Medical Research and Nutrition Laboratory. Fitzsimmons General Hospital. Denver, Colorado, 1958-1960.
Academic Positions Held:
Clinical Instructor in Medicine, University of Colorado, 1959-1960.
Senior Registrar in Cardiology Department, Brompton Hospital, London University, 1960-1961.
Instructor in Medicine, Director, Cardiopulmonary Division, Washington University School of Medicine, 1960-1962.
Assistant Professor, Washington University, 1962.
Assistant Physician, Barnes Hospital, St. Louis, Missouri, July, 1961-1962.
Associate Professor of Medicine, Duke University, 1962-1969.
Chief, Medical Service, Veterans Administration Hospital, Durham, North Carolina 1963-1968.
Director, Division of Environmental Medicine, Department of Medicine, Medical Center, 1968-1973.
Consultant, Durham Veterans Administration Hospital, Fayetteville Veterans Administration and Oteen Veterans Administration Hospital, North Carolina, 1968-1973.
Recipient of Research Career Development Award 1-K4-ES-8111 from the National Institute of Environmental Health Sciences, June, 1969.
Associate Professor of Medicine and Assistant Professor of Anatomy, Duke University, 1969-1970.
Professor of Medicine and Assistant Professor of Anatomy, Duke University, 1970-1973.
Professor of Medicine, Associate Professor of Anatomy, University of Missouri-Columbia 1973-1977. Director, Division of Pulmonary and Environmental Medicine, 1973-1977.
Professor of Medicine and Professor of Community Medicine, Environmental Sciences Lab, Mt Sinai School of Medicine, 1977-1980.
Professor of Medicine, University of Southern California, 1980-2000.
Director, Barlow Occupational Health Center, 1982-1984.
Chief, Pulmonary and Environmental Medicine Section LAC-USC Medical Center, 1982-1984.
Administrative Experience:
Directed Surgical Division of U.S. Army Medical Research and Nutrition Laboratory - Fitzsimons General Hospital, Denver, Colorado. 1958-1960
Senior Registrar British Health Service, Brompton Hospital, University of London. 1960-1961
Director, Division of Cardio-respiratory Medicine, Washington University, St. Louis, MO. 1961-1962
Chief, Medical Services, Durham Veterans Administration Medical Center of Duke University Medical Center, Durham, NC. 1962-1968
Director, Division of Environmental Medicine, Duke University Medical Center, Durham, NC. 1968-1973
Director, Pulmonary and Environmental Medicine Division, Department of Medicine, University of Missouri-Columbia, Columbia, MO. 1973-1977
Chief of Research, Pulmonary Division, Member Environmental Sciences Laboratory and Chief, Pulmonary Disease Service, Bronx VA Hospital, Mount Sinai School of Medicine. 1977-1980
Founding Director, Barlow Occupational Health Center, University of Southern California, Los Angeles, CA. 1980-1984
President and Medical Director, Workers Disease Detection Services Inc., San Dimas, CA. 1980-1994
Director, Environmental Sciences Laboratory, Department of Medicine, University of Southern California Keck School of Medicine, Los Angeles, CA. 1980-Present
President & Director, Neuro-Test, Inc. 1994-Present
Professional Societies:
American Association for Advancement of Science.
American Medical Association.
American Thoracic Society, Committee on Therapy 1965-1967;
Nomenclature Committee 1972.
American Federation for Clinical Research.
Southern Society for Clinical Investigation.
American Physiological Society.
American Heart Association.
Sigma Xi.
American Occupational and Environmental Health Society.
American Society for Experimental Pathology.
Central Society for Clinical Research.
American Society for Cell Biology.
International Epidemiological Association.
American Public Health Association.
Western Association of Physicians.
Colleqium Ramazzini.
National Committees:
Member, Veterans Administration Pulmonary Disease Research Evaluation Committee, 1963-1969.
Member, Veterans Administration Cardiopulmonary Training Committee, 1968-1975.
Member, American Thoracic Society Committee on Anti-Smoking, 1969-1972.
Member, National Air Conservation Commission, 1970.
Member, Lung Center Grant Review Committee, National Heart and Lung Institute, 1971.
Member, Ad Hoc Air Pollution Control Office Research Grant review Committee, 1971.
Member, Pulmonary Academic Award Committee, NHLI, 1974-76.
Member, Research Evaluation Committee, National Cystic Fibrosis Society, 1974-78, Education Committee, 1977-78.
Member, Advisory Committee to Surgeon General on Paraquat and other Herbicides, on Marijuana, 1978.
Scientific Advisor to Workers' Institute for Safety and Health 1979.
Member, Committee on Byssinosis, Assembly on Life Sciences, National Research Council, 1979-1981.
Member, Board of Scientific Counselors, Division of Cancer Prevention and Control, National Cancer Institute, 1980.
Member WHO Europe, Committee of Welding, Gases and Fumes Exposures, 1982-1986.
Member WHO Europe, Committee on Occupational Metal Exposures in the General Environment, 1982-1986.
International Committee on Neurobehavioral Methods in Occupational and Environmental Health, 1991-1993.
Committee: Future Doctors in Neurobehavioral Toxicology, 1990.
Education Activities:
Microanatomy course - first year medical curriculum, Duke University.
General medicine - second year ward and outpatient attending.
Lung Pathology - third year.
Environmental Medicine Course (Director) - third year.
Environmental Lung Seminar.
Pulmonary Medicine - fellows and residents.
Symposia:
Symposium on Structure, Function and Measurement of Respiratory Cilia, Duke University, February 12-14, 1965. Amer. Rev. Resp. Dis. 93: (part 2) 1-184, 1966.
An evaluation of Model Systems for Studying the Pulmonary Responses to Inhaled Materials, Bermuda, October 19-21, 1969, Arch. Int, Med. 126:415-511, 1970.
Pathogenesis of Bysinosis and Related Vegetable Dust Diseases, Quail Roost, North Carolina, April 1-May 1, 1970.
Cotton Dust and Health, Charlotte, North Carolina, May 2, 1970.
Hanford Conference on Pollution and Lung Biochemistry, Richland, Washington, June 3-6, 1970.
New York Academy of Sciences Symposium on Pulmonary Reactions to Organic Materials, New York City, November 8-11, 1972.
Tobacco Smoke Effects on the Non-Smoker, Bermuda, March 27-29, 1974, Co-Director with Dr. Ragnar Rylander.
Asbestos Associated Disease, New York City, November 27-29, 1978, Co-Director with Dr. Irving J. Selikoff.
International Meeting Monitoring of Exposure to Selected Chemicals and Their Health Effects, Berlin, West Germany, December 13-17, 1982.
Chronic Disease in the Workplace and Environment, Workplace Health Fund, Washington, D.C., November 30 - December 1, 1983.
International Conference on Health Hazards and Biological Effects of Welding Fumes and Gases. Cogenhagen, October 8-12, 1984. WHO-CEC (Planning Committee).
2nd International Symposium on Neurobehavioral Methods in Occupational and Environmental Health. Copenhagen - WHO’s Europe, Dec. 5-9, 1987.
3rd International Symposium on Neurobehavioral Methods in Occupational and Environmental Health. Pan American Health, Washington DC - WHO Americas Dec. 10-13, 1988.
4th International Symposium on Neurobehavioral Methods in Occupational and Environmental Health. Tokyo, Japan, 1991.
APHA Annual Meeting - SOEH Council meeting. Washington, DC, Nov. 8-12, 1992. Four presentations on pulmonary and neurological effects of environmental and occupational exposure to chemicals.
Grand Rounds - A Round-up of Inhaled Asbestos Disease. University of Texas. Tyler, TX Feb. 26, 1992.
Indoor Air Conference - Lung Association. Long Beach, CA May 7, 1992.
American Thoracic Society Conference. Miami Beach, FL May 16-20, 1992.
Indoor Air Conference - Lung Association. “Relating the Sick in the Building Syndrome to Hydrocarbons and Other Chemicals. Burbank, CA June 4, 1992.
ATSDR Meeting. Pulmonary test-toxic sub. “Devising Methods for Pulmonary Effects of Chemicals”. Atlanta, GA Aug. 12-14, 1992.
ATSDR Conference “Health Effects of Hazardous Waste”. Atlanta, GA May 3-5, 1993.
American Thoracic Society. San Francisco, CA May 16-20, 1993.
Scientific Assembly for Environmental Health. “Sensitive Tests for Neurobehavioral Toxicology of Chemicals”. Bethesda, MD Sept. 16-19, 1993.
Phoenix 200. Phoenix, AZ Oct. 15-17, 1993.
APHA Annual Meeting. Five presentations on Effects of Environmental Exposure to Chemicals on the Brain. San Francisco, CA Oct. 24-27, 1993.
CDC Workshop. Atlanta, GA Jan. 20-21, 1994.
ATSDR Neuroscience Meeting. Workshop of Sensitive Methods to Detect Chemical Effects on the Brain. Baltimore, MD April 6-7, 1994.
Health Effects of Malathion Panel. L.A. Convention Center, April 9, 1994.
El Pueblo Clinic. “Effects of Trichloroethylene on Health Especially Neurophysiological Dysfunction”. Tucson, AZ May 12, 1994.
Human and Ecosystem Health Effects of Industrial Activity. 2050 Project Meeting. “Effects on Human Health: Brain and Lung”. White Oaks, FL May 19-22, 1994.
Harbor UCLA Medical Center Conference. “How Inhaled Chemical Adversely Affect the Brain”. Los Angeles, CA Aug. 31, 1994.
American Public Health Association meeting. Washington, DC Oct. 30-Nov. 2, 1994.
Conference on Beryllium Related Diseases. Durham, NC Nov. 7-9, 1994.
Fifth Int’l. Symposium. Neurobehavioral Methods in Occupational and Environmental Health. Cairo, Egypt Dec. 3-9, 1994.
Chronic Epidemiological Studies Workshop. Washington, DC Jan 12-13, 1995.
Environmental Health Foundation National Conference. Oracle, AZ June 1-4, 1995.
International Conference on Arsenic Exposure & Health Effects. San Diego, CA June 12-13, 1995.
Approaches to Chemical Sensitivity. Sponsored by EOHSI and NIEHS. Princeton, NJ Sept. 20-22, 1995.
APHA Annual Meeting. Two presentations: Neurobehavioral effect of chlordane, and Hydrogen Sulfide. San Diego, CA Oct. 29-Nov. 2, 1995.
International Symposium on Man & His Environment. American Environmental Health Foundation. Dallas, TX Feb. 21-25, 1996.
APHA Annual Meeting. Poster presentation. New York, NY, Nov. 17-20, 1996.
Sixth International Symposium. Neurobehavioral Methods in Occupational and Environmental Health. Vision Neurobehavioral Testing Effect of Chlordane, Chlorine, and Hydrogen Sulfide, Shanghai, China October 12-13, 1997.
APHA Annual Meeting. Injury from Hydrogen Sulfide and Poster presented: Chlorine and Pyrethrin, Indianapolis, IN. November 10-13, 1997.
Editorial Responsibilities:
Archives of Environmental Health
Consulting Editor, 1970-1976
Executive Editor, 1976-1985
Editor-in-Chief, 1986-2006
Editorial Board:
American Journal of Physiology, 1973-1975
Environmental Research, 1970-present
Journal of Applied Physiology, 1973-1976
Associate Editor:
American Journal of Industrial Medicine, 1980-
Contributing Editor:
International Journal of Occupational Medicine and
Environmental Health
Guest Editor:
American Heart Journal
American Review of Respiratory Disease
Annals of Internal Medicine
Chest
Journal of Clinical Investigation
Occupational and Environmental Medicine
Environmental Health Perspectives
Neurotoxicology and Teratology
International Journal of Epidemiology
CAREER RESUME
Kaye H. Kilburn, M.D.
Dr. Kilburn graduated from the University of Utah College of Medicine in 1954. He completed postgraduate training in internal medicine at Western Reserve University (internship), University of Utah Hospitals (residency in Medicine and in Pathology), and Duke University (fellowship in cardio-pulmonary disease). In 1958, he developed a cardiopulmonary research laboratory with a staff of 15 at the U.S. Army Medical Research and Nutritional Laboratory at Fitzsimmons Army Hospital. Six papers were published. Following these two years, he trained in clinical cardiology with the late Dr. Paul Wood in London, England.
He returned to the United States in 1961 to organize the first cardiopulmonary division for Washington University (at Barnes Hospital), St. Louis. His effect on the house staff included 5 of 20 interns going into pulmonary disease.
He returned to Duke in 1963 to organize and head the medical service of the Durham Veterans Administration as an integral partner with Dr. Eugene Stead at Duke Hospital. Faculty and housestaff training was emphasized. The cardiology sections and pulmonary were strengthened including intensive care and research laboratories. Respiratory failure was studied prospectively together with clearance mechanisms of the lung and ciliary beating. After five years of administration a sabbatical was taken in ultrastructure of the lung.
A new and novel division of Environmental Medicine was developed and organized by Dr. Kilburn at Duke from 1968-73. The epidemiology of textile workers' lung disease (byssinosis) was pursued in cooperation with the North Carolina Department of Health and Burlington Industries, the textile giant. The basic biology of ciliary beating, of lung surfactant and glycoproteins in alveolar proteinosis and effects of inhalants such as cotton dust and cigarette smoke on airway lining cells were investigated in a model for scientific solving of societal problems. The division had a faculty of 12 and a staff of 25. Ten M.D.'s and Ph.D.'s were trained in environmental medicine each 2 years.
In 1973, Dr. Kilburn went to the University of Missouri to establish its first pulmonary and environmental medicine program.
In 1977, Dr. Kilburn returned to society's environmental and occupational medicine frontier by joining Dr. Irving J. Selikoff in the Environmental Sciences Laboratory at Mt. Sinai School of Medicine in New York. Among his roles was the development of "mechanisms of diseases" laboratories to complement Selikoff's epidemiological laboratories.
In 1980, Dr. Kilburn accepted the Ralph Edgington Chair in Medicine at the University of Southern California School of Medicine. In August of 1980, he founded the Barlow-USC Occupational Health Center as a clinical center for the investigation of the adverse health effects of environmental agents. The Pulmonary Division at USC School of Medicine and Los Angeles County-USC Medical Center, with its responsibilities for education, research and patient care, came under Dr. Kilburn's direction in July, 1982.
Research accomplishments included studies of shipyard workers and their household exposed family members which showed 11.3% of wives had signs of asbestosis. The nonsmoking women in this group showed airflow reductions attributed to Los Angeles air pollution. The repeat study of 330 of these women, four years after the initial study confirmed the role of air pollution. Over 1,200 Los Angeles school children in 2nd and 5th grades were studied by spirometry for functional status as compared to Houston children as controls and by questionnaire for the prevalence of asthma, chronic bronchitis, the response to bronchodilators, and effects of household cigarette smoking and of Los Angeles smog. Not only were their pulmonary flows reduced as compared to those in Houston but their flows decreased across three years.
A longitudinal study of pulmonary and neurobehavioral effects of formaldehyde showed acute and progressive effects on pulmonary function. Furthermore, 6 of 10 neurobehavioral tests were reduced by hours of formaldehyde in regression analysis after age had reduced 8 of 10 tests.
A cross-shift study of stainless steel welding showed reduced flow rates during work, but more disturbing, cigarette-smoking welders had more functional impairment than smoking specific referents.
From 1986-1993 nearly 16,000 asbestos exposed shipyard and construction workers were studied to characterize the physiological impairments as obstruction of small airways with air trapping to reduced vital capacity and diffusing capacity. The under- measurement of total lung capacity using gas dilution was defined. These asbestosis studies and normal values for total lung capacity based on standard population were published.
Since 1986, following the study of neurobehavioral performance in histology technicians, nearly 2400 subjects exposed to environmental chemicals have been characterized by neurophysiological tests of balance, reaction time, blink reflex latency, color discrimination and a cognitive and perceptual motor test battery including affective status with a profile of mood states. Toluene, trichloroethylene, hydrogen sulfide and chlorinated dibenzodioxanes are the major neurotoxicants associated with impaired performance. Apparatus for field testing of balance, blink and reaction time have been developed and tested and results published. These studies have led to over 10 publications and 12 papers and two books are in development.
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